MITO
(Mitochondrial Stress Test)
This study evaluates energy output in HD patients during physical exercise. The study is a collaboration between Southwestern Medical Center in Dallas, Texas and CHDI, Inc. The Study length is 6-8 Weeks.
The study will recruit:
- Adults 25-65 yrs of age
Participants are very/fairly high functioning (UHDRS TFC score of 8 or greater)
- Patients must be psychiatrically stable
- Benzodiazepines/Antipsychotics/Beta Blockers must be excluded 2 weeks prior to and during study period
- Creatine, CoQ10, and high dose Vitamin E must be excluded 4 weeks prior to and during the study period
- Patients must be on stable doses of all other meds 4 weeks prior to entering study
- A caregiver is preferred, but not required
- Subjects will be seen at Wake Forest University for eligibility and then complete 1 day of exercise testing in Dallas, TX
- Travel is paid for subject and caregiver
- For more information, contact Christine O’Neill at Wake Forest University.
The requirements listed above are not comprehensive. Study subjects must meet all of the individual study protocol criteria and in the opinion of the site study doctor and the sponsor’s medical monitor have the ability to participate in and complete the study.
